產(chǎn)品介紹

ω-CONOTOXIN GVIA / Omega conotoxin GVIA (ω-漏斗網(wǎng)蛛毒素GVIA)

Selective blocker of Ca_v2.2 channel 

Cav2.2 通道選擇性阻斷劑

ω-conotoxin GVIA (omega conotoxin GVIA) has been isolated from the venom of the cone Conus geographus. ω-conotoxin GVIA acts at presynaptic membranes. It binds and blocks specifically voltage-dependent N-type Ca²⁺channels Ca_v2.2 channel with an ED₅₀ of 68pM.

ω-conotoxin GVIA(ω-漏斗網(wǎng)蛛毒素GVIA)技術資料

氨基酸序列：

H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂  （Hyp: hydroxyproline）

二硫鍵： Disulfide bonds between Cys¹-Cys¹⁶, Cys⁸-Cys¹⁹ and Cys¹⁵-Cys²⁶

長度 (aa)： 27

分子式： C₁₂₀H₁₈₂N₃₈O₄₃S₆ 

分子量： 3036.05 Da

外觀： White lyophilized solid

可溶性： water and saline buffer

CAS 號：[106375-28-4]

來源：Synthetic 

純度： > 95 %

產(chǎn)品信息